Thursday 17 May 2012

Beta Blockers


Beta Blockers


Comparative information
  
Pharmacological differences

  • Agents with intrinsic sympathomimetic action (ISA)
    • Acebutolol, carteolol, celiprolol, mepindolol, oxprenolol, pindolol
  • Agents with greater aqueous solubility (hydrophilic beta blockers)
    • Atenolol, celiprolol, nadolol, sotalol
  • Agents with membrane stabilizing effect
    • Acebutolol, betaxolol, pindolol, propranolol
  • Agents with antioxidant effect
    • Carvedilol, nebivolol
Indication differences

  • Agents specifically indicated for cardiac arrhythmia
    • Esmolol, sotalol, landiolol
  • Agents specifically indicated for congestive heart failure
    • Bisoprolol, carvedilol, sustained-release metoprolol, nebivolol
  • Agents specifically indicated for glaucoma
    • Betaxolol, carteolol, levobunolol, metipranolol, timolol
  • Agents specifically indicated for myocardial infarction
    • Atenolol, metoprolol, propranolol
  • Agents specifically indicated for migraine prophylaxis
    • Timolol, propranolol

Propranolol
is the only agent indicated for control of tremor, portal hypertension,
and esophageal variceal bleeding, and used in conjunction with
α-blocker therapy in phaeochromocytoma.

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