alkylating agents in chemotherapy
Alkylating agents in cancer therapy:
Nitrogen mustards cyclophosphamide, estramustine, melphalan, chlorambucil
Nitrosoureas chloroethylnitrosourea, lomustine, carmustine
Busulfan
Others thiotepa, treosulfan
Platinum comp’s cisplatin, carboplatin, oxaliplatin
Dacarbazine ( prodrug )
Temozolimide
Harmful:
Lomustine delayed, cumulative myelotoxicity
Cisplatin low myelotoxicity
Carboplatin high myelotoxicity
Cyclophosphamide haemorrhagic cystitis (ifosfamide)
Acrolein
Beneficial:
Estramustine prostate cancer
Busulfan chronic granulocytic leukemia
Nitrosoureas tumors of brain and meanings
Cisplatin germ cell tumor
Temozolimide malignant glioma
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