BASIC NUCLEUS - Medicinal Chemistry

BASIC NUCLEUS

DRUG and their MOEITY

GENERAL ANAESTHETICS

1. Etomidate- Imidazole

2. Propofo = l(diprivan) 2,6-diisobutylphenol(given in emulsion form)

3. Alphaxalolne = pregneane

4. Ketamine = Cyclohexanone

5. Thiopental = Barbitone(pyrimidine dione)

LOCAL ANAESTHETICS

1. Bupivacaine,mepivacaine = Piperidine

2. Ropivacaine = Pyridine

3. Dibucaine = Quinolone(benzpyridine)

4. Dimethisoquine = Isoquinoline

5. Fomocaine,pramoxine = Morpholine

6. Euprocin = Rubane

7. Myrtecain =e Norborane

OPIOIDS ANALGESICS

1. Pholcodine = Morpholine

2. Racemoramide = Morpholine,pyrrolidine

3. Methadone = Diphenylacetonitrile+1-dimethy

lamino-2-

propylchloride

NSAIDS

1. Salicylic acid =(acetylation)

2. Piroxicam = Pyridine,1,2-benzothiazine

3. Phenylbutazone = Pyrazole

4. Sulfinpyrazole = Pyrazole

5. Indomethacine = Indole

6. Sulindac = Indene

7. Tolmetin = ,zomepirac pyrrole

SEDATIVEHYPNOTIC/SOPORIFIC/

ANXIOLYTICS

1. Flumazeni = l BDZ fused with imidazole

2. Alprazolam,triazolam = BDZ fused with triazole

3. Midazolam = BDZ fused with imidazole

4. Zolpidem = Pyridine fused with imidazole

5. Zaleplon = Pyrimidine fused with pyrazole

6. Glutethimide = Piperidine dione

7. Paraldehyd e = Trioxane

=

ANTI-PSYCHOTICS

1. Thioridazine, = mesoridazine Piperidine

2. Prochlorperazine = ,perphenazine,fluphenazine Piperazine

3. Loxepine = Dibenzooxazepine + piperazine

4. Thiothixene = Thioxanthene + piperazine

=

5. Clozapine ==== Dibenzodiazepine + piperazine

6. Droperidole = Indolinone + pyridine(partially saturated)

7. Risperidone = Benzoisoxazole,pyrimidine fused with pipridine

8. Pimozide === Benzimidazolidone

9. Molindone = Morpholine,pyrrole

10. Sulpride = ,remoxipride Pyrrolidine

11. Olanzapine = Thiophene,benzoazepine,piperazine