Thursday 17 May 2012

GPAT & NIPER JEE Question-6


GPAT & NIPER JEE Question-6


Expanded Access IND" is the other term for Which IND?    
A.Investigator IND
B.Emergency Use IND
C.Treatment IND
D.All of these,


All of the following are water insoluble alkaloids except
a) ergometrine
b) ergotamine¿
c) ergocristine¿
d) ergocornine
A,


>MORPHINE- mu receptor agonist.
>NALOXONE, NALTREXONE- narcotic antagonists.
>NALBUPHINE-mu antagonist &k receptor agonist.,


BCG vaccine given by Sc route,


MOLECULAR MODELLING SOFTWARES
>Chem3D
>Alchemy
>Sybyl
>Hyperchem
>ChemX
>Discovery studio pro
>CAChe,


Most of the protein amino acids have S-configuration except
a) L-Alanine
b) L-Proline
c) L-Cysteine
d) L-Serine
C,


Which one of the following tetracycline have ADH antagonistic action
a)demeclocycline
b)minocycline
c)doxycycline
d)all,


How many chiral centers are there in Pinene
A.1         
B.2         
C.3         
D.None,


HIV test may be shown NEGATIVE in WINDOW PERIOD although HIV virus present in body. Thus test must be repeated after 6months.,


Mohit@NIPER: Crystal urea causing drugs:
Sulphonamide,
(In high dose:Thiabendazole,Ciprofloxacin,Methanamine,methotrexate),


NAA: Do anticancer and Antihiv drugs from Kokate with special importance to marine sources... NAA registered student wil get this list...,


VNGoyani: Do all the name reaction from Morrison & Boyed and J.march.

Do Stereochemistry from M.& B.
Most of question are on these topics,


Reducing sugars:GALACTOSE,LACTOSE,FRUCTOSE..Non reducing sugars:SUCROSE,TREHALOSE..Width of double helix dna:,


Dificid (fidaxomicin) is a macrolide antibacterial drug indicated for the treatment of Clostridium difficile-associated diarrhea.
,


Pinacol - Pinacolone reaction is an example of
a)acid catalysed
b)base catalysed
c)H2/Pt
d)none


Configuration of Tartaric Acid is
A.3R 3S      
B.3R 2R        
C.2R 3R     
D.None,


Phase inversion temperature is also known as ' HLB' temperature.
Read about cyclodextrins,NDDS,Non-linear pkinetics in Brahmankar.they r very imp,


Read all about AIDS & HIV tests. It's very imp for all exams.
* If HIV test found +ve then this is confirmed by Western Blot Test & Polymerase chai,


FDA 2day approvd Dificid (fidaxomicin) a macrolide antibacterial drug indicated for the treatment of Clostridium difficile-associated diarrhea.,


Curtius reaction is a conversion of
a)acylazide to isocynate
b)isocynate to acylazide
c)nitrile to acid
d)none,


Near IR range is at ( in micron)
A.0.8 - 2          
B.2 - 15            
C.15 - 1000           
D.none,


 US FDA approved Edurant (rilpivirine)for treatment of HIV-1 infection in adults who never took HIV therapy.Do newly approved drugs for NIPER,



NAA: Do all name rxns around 120-130 frm Jerry march.
Also remeber tthe stereochem part very nicely.
If u join NAA NIPER kit all NIPER materials th,


SAMP is an example of _______.
a)chiral auxillary
b)chiral substrate
c)chiral catalyst
d)none,


Indian Pharmacopoeia is published by
-Ministry of Health and Family Welfare
First Edition of Indian Pharmacopoeia was published in
-1955,


Diel's - Alder reaction is an example of
A.Cycloaddition reaction   
B.Pericyclic reaction      
C.Sigmatropic reaction   
D.none of the above,


Hexahelicene shows chirality due to ________.
a)chiral axis
b)helical shape
c)chiral point
d)chiral carbon,


All ______ reactions are ____.
a) stereoselective, stereospecific
b) stereospecific, stereoselective
c) synthetic, asymmetric,


Indian Nobel prize winners
Hargobind Khorana (Nobel Prize in Medicine -1968)
Mother Teresa (Nobel Peace Prize in 1979)
Register for best postal,



The presence of thiophene in benzene is detected by the reaction
a)Howarth
b)indophenin
c)both
d)none,


the glomerular filteration rate is 130ml/min
the amount of body cholesterol 250 mg/dl,


Amorphous substance do not have melting point but glass transition temperature.
ciclosporin is the drug which has 1200 M.W bt absorbed by GIT



UTI work for
a)Mobilization of saving people
b)Provide homes for public
c)both
d) none of these


VNGoyani: Which type of energy bring about U.V transitions
A)Electronic
B)Vibrational
C)Rotational
D) All of the above


NIPERites: Organisms called slime molds have characteristics of both fungi and amoebas.production of mono anti-bodies was first invented by Cesar Mil



sandip: Bombay:
Central Drug Testing Laboratory (CDTL)
Indian Drug Manufacturing Association (IDMA)
National Plasma Fractionation Centre



VNGoyani: A solid of density D is floating in liquid of density d.If v is vol. of solid submerged in liq & V is total vol.of solid.Then v/V=
D/d



In 5HT Recep all r G PROTEIN COUPLED receptors except 5HT3.As 5HT3 is a LIGAND GATED.. 5HT1D,5HT2A AGONIST(METHYSERGIDE)Use:Migraine


Total time required for one cycle of PCR is
a)3 minute
b)10 minute
c)15 minute
d)30 minute
A


IL-1 is called endogenous pyrogen
No of amioacids in insulin is 51
St. johns wart is called hyperforin and it is antideprssant.phenytoin non-lin



 PHOTOCHEMISTRY :-
the reaction which take place whwn molecules absorb ultraviolet or visible radiation are called photochemical reaction.


tertiary protein structurs:-insuline
qurternary:- haemoglobin, enzymes
primary protein structure is linear,all other 3 are non linear


VNGoyani: What is the total number of pi bonds found in the 1-nitro propyne?
a) 1
b) 3
c) 2
d) 4
ans.d


Turbolent flow start when Reynolds' number
-greater than 4000
List principle of all mills n specific use of mills.


VNGoyani: What a Polymer that is which softens upon the absorption of water & is used to make contact lenses?


HARISHARORA
Walden Inversion occurs in
a) SN2 reaction
b) SN1 reaction
c) SNi reaction
d) all.most imp ques being askd almost each year in NIPER exams


GUNTURACADEMY
Rajesh: Rxn in which stereochemically diff molecules react differently-STEREOSPECIFIC RXN..D4 receptor polymorphism-SCHIZOPHRENIA


he concentration of dispersed phase in parentral suspension should be 1-30.
the amount of moisture in acacia nd digitalis is 15 nd 5 % rspective,


study abt DSC,TGA,XRD very briefly.vitamins,PCR,human genome project,monoclonal antibodies,pencillin fermentation,taxol side chain cal-09780924943,



NIPERites: The system of nomenclature (naming) for organisms used today was established in 1735 by Carolus Linnaeus,



domain:-
it is related to protein structure which is responsible for the function of that particular protein


 Rxn which yields predominantly one stereoisomer(or one pr of enantiomers) of several possible diastereomers-STEREOSELECTIVE RXN



VNGoyani: Intestinal microbes synthesize:
> Vitamin B12
> biotin
> pantothenic acid
> vit.K


do named reactions fm Kalsi and Morrision n boyd. cell culture nd growth of bacteria fm micro part. and ask any querries regarding niper


SQC stands for
a)Standard quality control
b)Statistical quality control
c)Specific quality control
d) none
B


) Resolution of amino acid racemic mixture using hog kidney acylase is ____  resolution.
a)destructive
b)kinetic
c)both a n b
d)none of the



Kauntay: Photosensitization:-
A molecule in an excited state may transfer its all excess energy at a time to a different compound in the same enviro


Central rice research institute is located in -Orissa
Accelerated stability study is done at 40 C & 75% RH


Back titration,
acid base indicators,
Clinical trial details,
Ramchandran plot,
Nogami plot,
IR,NMR values,


VNGoyani: Correction:
Which instrument is not possible
A) FT-NMR
B) FT-UV
C) FT-IR
D)All are possible


NIPERites: free trade port=kandla
Rmchndrn plot=2 structure
Rectal suppository=2g
read types of stomata,excipients frm Remington


bepotastine ophthalmic solution is an antihistamine and mast cell stabilizer for treatment of the symptoms of allergic conjunctivitis.


Important synonyms for NIPER
Aborigine-Primitive inhabitant
Abortive-Unsuccessful
Abstinence-Restrained eating or drinking
All r included in N-



Hexahelicene shows chirality due to ________.
a)chiral axis
b)helical shape
c)chiral point
d)chiral carbon



Coumarin glycosides are derivative of
a)Benzo- alpha Pyrone
b)benzo- beta Pyrone
c)Lactone
d)none


VNGoyani: 2nd generation
Atazanavir
Darunavir
Tipranavir


Raltegravir belongs to which class of anti HIV?


ans.Integrase inhibitors


US FDA approved Edurant (rilpivirine)for treatment of HIV-1 infection in adults who never took HIV therapy.Do newly approved drugs for NIPER



USA is the highest cotton producing country (EVANS)
.gamma cyclodextrin is mos soluble
1-beta is called power of test in hypothesis testing.bst



PFK is activated by
a)fructose 2,6 - bisphosphate
b)ATP
c)both
d) only (a)


Biochemical target in pharmaceutical lead discovery may be
a)Enzymes
b)Receptor
c)Ion channels
d)All of these


Mohit@NIPER: read abt crystal habit,polymorphism,Amorphorphous forms,Viscosity(types os flow) from CVS or Martin.softwares names n uses from Foye



Pseudomembrane colitis is adverse effect of
a)chloramphenicol
b)streptogramins
c)clindamycin
d)none


For non-dissolution rate absorption the IDR value must be more than 1gm/cm2/sec
mercury is used for measuring granule density


FT- NMR used in
a)Change in frequency to time data
b)Change in time to frequency data
c)both  a &  b
d)none of these
C


Denosumab:RANK ligand inhibitor indicated 4 prevention of skeletal-related events in patients with bone metastases from solid tumors



 read briefly abt Cyclodextrin,complexation from Martin,seive sizes, sterilization conditions,Cell organells,Nobel prizes from Bio/Med f



 saxagliptin:
dipeptidyl peptidase-4 (DPP-4) inhibitor Use for the treatment of type 2 diabetes.
New drug for niper-jee 2011



Liebig -Pregl Method for determination of carbon and hydrogen
Zero dipole moment-carbon tetrachloride, methane,carbon dioxide.



mportant synonyms for NIPER
Aborigine-Primitive inhabitant
Abortive-Unsuccessful
Abstinence-Restrained eating or drinking



gods own country - kerala
indigen is part of which pharma giant?find
no of rabbits for sterility testing find?
SEZ-specisl economic zone.bst lu


Abzyme=antibody hving catalytic activity.
Totipotency=ability of single cell to divide&produce all differentiated cell in organism


Cedar wood oil is used in .......Magnification
a)4x¿
b)10x
c)40x
d)100x
D



NIPERs favourite topics:
receptors
Stereo
Marine drugs,clove,taxol
mass,ir,uv,nmr,cd
chromatography
rules of chemistry,biomole
cal us for m



Watson & ....... Announced discovery of DNA structure in.......
a)Sanger,1960
b)Crick,1953
c)Crick,1960
d)Sanger,1953
ans: B



NIPERites: Disintegrent is not used in
a) Buccal b) Sublingual c) Coated tablet d) all
Ans=b.


 vilazodon use for major depressive disorder.
spinosad is pediculicide indicated for the topical treatment of head lice infestations



FT- NMR used in
a)Change in frequency to time data
b)Change in time to frequency data
c)both  a &  b
d)none of these
C



NIPERites: What is the total number of pi bonds found in the 1-nitro propyne?
a) 1
b) 3
c) 2
d) 4
ans.d



: Investigational New Drug Application-for newly synthesized molecule after testing safty in animals,i.e.preclinical studies.



Find the missing number 10, 67, 130, 223, ?
a) 352
b) 357
c) 348
d) 373

ans: c


IDIOSYNCRACY (type-B ADR)
chloramphenicol-aplastic anaemia
primaqine-heamolysis
diclofenac-kidney damage
streptomycin-kidney damage
read in r



Orientation in Baroda on 4th
Rushinad classes,
Karamdham 3rd floor,
Productivity road
Akota.



elimumab:
B-lymphocyte stimulator (BLyS)-specific inhibitor indicated for the treatment of Systemic Lupus Erythematosus



Carbon free radical is sp2 hybridized
3>2>1>methyl
Overall carbocation stability:
3>1 benzyl>1 allyl>2>1>vinyl>methyl



Microdosing is directly given to patient without preclinical testing in which phase
a)0 Phase
b)I Phase
c)II Phase¿
d)III Phase
A


PHARMAGLIMPS-2
Aspartame, which is a synthetic sweetener is
a) dipeptide
b) tripeptide
c) lipidic substance
d) none


For absorption of iron, ferric ion is converted into
a)Fe+2
b)Fe+1
c)both
d) only (a)


HTS means
a)High throughput screening
b)Herbal Therapeutic survey
c)Both a & b
d)none of these



pharmaosmosis
what is the effect of polymer on glass transition temperature?
a. increase
b. decrease
c.no change
d. cant say
ans-A


VNGoyani: 4.Esomeprazole
5.Amlodipine
6.Infliximab, J&J
7.Etanercept
8.Olanzapine,eli lili



The synonym of abduct
a)Confined
b)Bound
c)Released
d)absolve
ans: A



VNGoyani: Also some topic should be om tip of tongue are:
New approved drugs,
Name of nobel prize winner,
Cology classification,
name reaction


In Markonikov's Rule, the intermediate formed is
a) carbanion
b) carbocation
c) free radical
d) all
Target



VANDETANIB:kinase inhbtr..Treat THYROID CANCER.
Ulman rxn: SYN OF DIPHENYL AMINE,DIPHENYL ETHERS,DIPHENYLS.



Zeta potential determined by micro electrophoresis, electro-osmosis, sedimentation potential or streaming potential.



gamma cyclodextrin has higher water solubility & does not cause nephrotoxicity & has largest cavity



fidaxomicin is a macrolide antibacterial drug indicated for the treatment of Clostridium difficile-associated diarrhea.



NIPERites: When product patent started in India?
A) 2003 B) 2005 C) 2009 D) 1985
Ans 2005



VNGoyani: TOP 10 Selling drug:
1: Lipitor (Atorvastatin) pfizer
2:Advair, Seretide(Fluticasone + Salmeterol) GSK
3:Plavix(Clopidogrel) BMS



pharmexcel
Samir: 2+3=30
7+2=126
6+5=330
8+4=384
Then
9+7=??
Ans:1008
(2+3)*(2*3)=30
(7+2)*(7*2)=126
(6+5)*(6*5)=330
(8+4)*(8*4)=384
So,(9+7)*(9*7)=1



HARISHARORA
An anticancer agent derived from an amino acid (phenylalanine) is a) busulphan b) malphalen c) thiotepa d) lomustine e) mesna.



PHARMAPOINT
Evaporation rates at Room Temp.
Ether >acetone >chloroform >CCl4 >ethyl acetate >water.
#Plz sms any pharma news to 09503748384-Guru.



pharmaosmosis
indian partnership ct 1932
indian tax act-1956
current 5 year planning is 11th nd will end in 2012
benting discovered insulin,sanger gave srctu



Which one the following is haemopoietic factor/s
a)Epoetin
b)Filgarstim
c)molgramostin
d)all
Join best N_pac



GATEPY2009
NAA: Solvents used in IR:
non-aqeous: CHCl3,CS2,CCl4
Nujol shows absorption at: 719,1376,1462,2915 cm-1
plz do IR ranges(near,mid,far),UV,NMR.



GUNTURACADEMY
Rajesh: Long actng statin:ATORVASTATIN.Best drug..Lepitor brand name..Synthetic pentasacharide heparin fragment:FONDAPARINASE[Ad] Cashless Treatment in 800 Cities! SMS APL to 56070



pharmexcel
VNGoyani: One of the following is aprotic solvent
a) Dimethylsulfoxide (DMSO)
b) Dimethyl formamide
c) Hexamethylphosphorotriamide (HMPT)
d)



pharmaosmosis
ferquently askes name rxn:
curtuis,Wittig,chichibhabin,makoniokov,kharash,calsen,clemmenson,zeisels,shapiro,suzuki,negishi,ozonolysis,grignard et



pharmexcel
VNGoyani: Which is biggest cotton producing country in the world?
a)India
b)China
c)Pakistan
d)Shrilanka

4 such GK question

ON 4success



Chronic candidiasis infections of G.I. tract & oral cavity treated orally with
a)Amphotericin B
b)Nystatin
c)Miconazole
d)Fluconazole


GUNTURACADEMY
Rajesh: Minister of chemicals&fertilizers of central govt:ALAGIRI..Aspargine:N,glutamine-Q,lysine-k,Aspartic acid:D,glutamic a'-E,Tryptophan:W



Active form of artemisinin:DIHYDRO ARTEMESININ..Side eft:NEUTROPENIA..Doc 4 CEREBRAL MALARIA..AMES,CHROMOSOMAL ABERATN TEST:Mutagenicity.
[Ad] Cashless Treatment in 800 Cities! SMS APL to 56070



drug receptor interaction is a exothermic reaction.
first planning commission set up in 1950 nd fist plan in 1951.
Jacob nd monad -lac operon co


Threose and Erythrose are
a) Diastereomer
b) Enantiomer
c) syn isomer
d) anti isomer


Matrix in MALDI - Benzoic,cinnamic,cinapinic etc.
MS MS -s MAss spectrometers in series.
Which is endogenous anticonvulsant?
find.
read abt va



PHARMAGLIMPS-2
Tartaric Acid is
A.2,3 Dihydroxy butane dioic acid         
B.1,2 Dihydroxy butane dioic acid                
C.1,3 Dihydroxy butane dioic



pharmexcel
VNGoyani: boceprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated for the treatment of chronic hepatitis C.



Highest first pass metabolism shown by-
verapamil,
propranolol,
propoxyphen,
pethidine,
methyl testosteron,
salbutamol,
nitroglycerin.
-Have


VNGoyani: Phenomenon of introduction of DNA into host bacteria is called:
a)Transversion
b)translocation
c)Transformation
d)Transduction

ans:


Peptic ulcer is need to be treated using Antibiotics Only if it is caused by microbes like Hellicobacter Pylori.
# # # # # #



HARISHARORA
if GLARE is coded as 67810 & MANSOON as 2395339 then how can
RANSOM be coded
a)183952
b)198532
c)189352
d)189532.my best wishes wid u all




PHARMAGLIMPS
Psychrometric chart is related to
a)Osmotic pressure
b)Humidity
c)solubility
d) evaporation
B
Choose best option for ur future
pharmaglimps.



pharmaosmosis
trde name
binders:
luvitec:PVP
Walocel:HPMC
diluents:
cel-tab:Cal. carbonate + malto dextrins
Di-Pac-sucrose+maltodextrins.all dis in our po



1)Clinistrips test quantitatively test for sugar in urine.
2)The Kastle-Meyer test tests for the presence of blood
call 07814564264 for any quer


PHARMAGLIMPS
Dielectric const. of water at 250C is
a) 78.5
b) 56.5
c) 78.0
d) 77.5



Mutually exclusive events have probabaility 1.
If there is meso formation the no. of isomers is equal to less than 2^n
read about crams rule


VNGoyani: IUPAC name, solvent propery,solubility order, bonding, chemistry of protein and carbohydrates, reaction order, physiochemical property


PHARMAGLIMPS-2
quinidine dextroisomer -antiarrythmatic,
quinine ievo isomer- antimalarial
cold creams -W/O emulsion
vanishing cream - O/W emulsion
078145642


PHARMAGLIMPS-2
CH3-CH=CH2+HBr
a)CH3-CH2-CH2Br
b)CH3-CHBr-CH3
c)CH2Br-CH2Br-CH3
d) BrCH2-CH2-CH2Br
See anti Markovnikov addition
Best NIPER-pack at ur door
[Ad] Buy an office PC powered by Windows 7 Professional. To get a quote SMS WIN7 to 9212174636



 WIPO-WORLD INTELLECTUAL PROPERTY ORGANISATION..Comb of circular dichroism&circular bifrigence:COTTON EFFECT..All enzymes r CHIRAL.



GATEPY2009
NAA: BT is used as opposed to standard volumetric titration when the substance being analyzed is either too weak to give a valid reaction


GATEPY2009
Mohit@NIPER: Drugs producing St.Johnsn Synd:
S:Sulphonamide
A:Amprenavir
F:Fluconazole
I:Itraconazole
T:Thiabendazole


HARISHARORA
"HENBANE"  is the common name of a) stramonium b) hyoscyamus c) belladona d) cinchona.send ON PHARMATRAIN to 9870807070



VNGoyani: All of the following are stop codon except
a)UGA
b)UGC
c)UAG
d)AUG

Do DNA replication,translation from styanarayan.


ans:b



# Remember all schedules in D&C act.
# ART drugs (drugs used in HIV infection).
# do drug classification from book by Vikas seth.
>GUD MORNing<


______ is optically active.
a) glucose
b)2-bromobutanol
c)D-glyceraldehydeç
d) All of the above


IMP FOR NIPER:biostatistics, nobel prize winner in Medicine, imp GK, Recent FDA approvals & pharma news, imp full forms, imp govt institutes.

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