Thursday 17 May 2012

IMP GPAT Notes - 2


SUCROSE BASED DILUANTS 
Dipac -97%sucrose+3% moddified dextrose
Nutab -95%sucrose+4% invert sugar
Sugar tab -90-93%sucrose+7-10%invert sugar



Spans 20=Sorbitan mono laurate
Tween 80=Polyoxyethylene sorbitan monooleate 
L:Laurate-20
P:Palmitate-40
S:Stearate-60
O:Oleate-80
remembr d



PROPORTIONS REQUIRED FOR A PRIMARY EMULSION 
(oil:water:gum)
Fixed oils :-4:2:1
Volatile oils:- 2:2:1
Mineral oils:-3:2:1
Oleoresins:-1:2:1


What is ALCON & POLYQUAD used in Opthalmic?
A) Preservative
B) Solubility enhancer
C) Antioxidant
D) All of above
ans=A...



OH shows a characterstic IR peak at cm-1 a) 1725 b) 3200 c) 3650 d) 2300
ans=c..
Do all IR peaks from std books like Pavi/Skoog/silver stein.



Guanidium thiocyanate, CTAB-cetyl trimethyl ammonium bromide,
Ethidium bromide-this all are uesd in DNA isolation.



Amide is converted in to amine.
identify the rearrangement
a)Backmann
b)Curtius
c)Pinacole
d)Hoffmann
ans=d.



plz remember this values....

DIGITALIS:1 IU=76mg std
VIT A:1 IU=0.344mg std
VIT D:1 IU=0.025mg std
Heparin:1 IU=7.7mg std
INSULIN 1 IU=0.




Sodium glucose co-transporter-2 (SGLT2) inhibiting antidiabetics:
Canagliflozin
Dapagliflozin,
Remogliflozin,
Sergliflozin.
This is new class.



Drug usd in severe Alzeimer's disease:
A.Memantine
B.Ifenprodin
C.Aniracetam
D.Neostigmine
Ans=A


GABA-B agonist is:
A.Phaclofen
B.Baclofen
C.Saclofen
D.All of above
ans=d..


Donepezil, Isoflurophate & Neostigmine are anticholinesterase with longer action..
edrophonium-shorter acting anticholinesterase.



DRUG-SYNONYM
Devil's dung-Asafoetida
Chaumogra oil-Hydnocarpus
Tylophora-Anantmul
Ephedra-Ma hung
Datura-Thorn apple
D.pupurea-Fox glove



Zanasi- capsule filling (powder,pellets,tablets)
Lily/parke-davis: capsule filling (powder)
Farmatic, holfiger & kary-liquid filling in HGC



Erweka:- De-dusting and polishing capsule machine.
Seidender- Uses a Belt for visual inspection.
Vericap 1200- capsule weighing machine


Penicillin G: benzyl penicilin
penicilin X: p-OH benzyl
Penicillin K: n-heptanyl
Penicillin V: phenoxy methyl
Penicillin F:2-pentanyl


Imipenam given with Cilastatin cz Cilastatin inhibits dehydopeptidase enzyme dt is responsible for hydrolysis of Imipenam.


In hepatic coma(encephalopathy), drug used are:
Lectulose,Neomycin,Metronidazole.



FOR TRANSDERMAL DRUG DELIVERY SYS:
DRUG:
LOW MELTING PT(<200 C)
POTENT
SHORTER T1/2
NONIONIC
LOG P VALUE(1-3)
MOL WT(<1000 DALTON)



Transdermal Drug Delivery Sys:
Major barrier dt prevent drug absorption is STRATUM CORNEUM,located in epidermis of skin,100-150 micron thick



Monitoring of plasma drug concentration is required while using:
A.Antihypertensive drug
B.Levodopa
C.Lithium carbonate
D.MAO inhibitor
ANS=C


Chitin gets converted in to Chitosan upon:
A.Acetylation
B.Deacetylation
C.Oxidation
D.Reduction
ANS=B..


which of the Anthelmintics having Immunosuppressant activity?
A.Piperazine
B.Levamisole
C.Ivermectin
D.Niclosamide 
ans=b..



Quinidine prolongs t1/2 of propafenone nd inhibits conversion of codiene 2 morphine.
Ergometrine is used in diagnosis of variant angina.

BENTONITE is a hydrated alluminum silicate
Veegum- is a magnesium alluminum silicate
acacia is a salt of d-glucuronic acid


time to reach Css is 
-dependent on t1/2 & Ke
-independent on dose size,dosing freq& dose number.


fenoldopam-selective dopamine D1 receptor agonist, for severe hypertension
Enalkerin-orally active renin inhibitor



penicillin-penam(ring)
Cephalosporins-cepham & cephem
clavulanic acid-oxopenam
thienamycin,imipenam,meropenam-carbapenam
aztreonam-monobactam


Method for Particle size determinatn-Anderson pipet
for Particle volume-Coulter counter
for surface area-Air permeability method.


(+) limonene present in lemon & orange
(-) limonene in peppermint
(+/-) presnt in turpentine.



(+) limonene present in lemon & orange
(-) limonene in peppermint
(+/-) presnt in turpentine.



Moxifloxacin & Gatifloxacin are 4th generation quinolones owing to dr activites against anerobes & S. pneumoniae.


Local anesthetic: Clove
Sedative: Jatamansi
Local irritant: Turpentine
Insect Repellant: Citronella oil
Vit A: lemon grass oil



 use of volatile oil c'ning drugs:
Anthelmintic: Chenopodium
Diuretic: Juniper
Antiseptic: Eucalyptus
Counter irritant: winter green


Shatavari contain 4 steroidal saponin: shatavarin I,II,III,IV
shatavarin I-anxiolytic
othr use of ds drug is-diuretic,galactogue..



Live vaccine-BCG
Dead vaccine-cholera & typhoid
Toxoid-diptheria
Ricketsial-typhus


Addition of HBr to cis-2-butene produces
A.1-bromobutane
B.2-bromobutane
C.1,2-dibromobutane
D.2,3-dibromobutane
ans=c..



Nanosuspension used 4 drug with poor solubility&low bioavaibility.
It incrs saturation solubility,dissolution velocity&adhesiveness to surface.


Electrostatically stabilized nanosuspensn hv min. (p'cle charge) zeta potential +/-30mv while steric&electrostatic stabilized hv min +/-20mv.


In-vivo evaluatn of Gastro retentive dosage form:gamma scintigraphy,gastroscopy,magnetic marker,ultrasonography,13C octanoic acid breath test

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