GPAT Question -3

One of the following determine rate of reaction

a) ΔH b) Eactivation c) Both a & b d) None of these

Le Bel and Vont Hoff are names related with

a) Racemic modification b) thermodynamics

c) tetrahedral geometry carbon d) free radical reactions

 One of the following is true:

a) 2Px, 2Py , 2Pz orbitals are of equal energy b) 2s is low energy orbital as compared to 1s

c) 2Px has lower energy than that of 2Py d) 2Px has higher energy than that of 2Py

Only two electrons of opposite spins can occupy an atomic orbital. This is

a) Pauli,s exclusion principle b) Plank’s rule c) Markovnikov’s rule d) none of these

 Hell-Volhard-Zelinsky reaction involves only α-halogenation of aliphatic carboxylic acids in

presence of small amount of

a) nitrogen b) Phosphorus c) sulphur d) peroxide

Disintegrent is not used in

a) Buccal b) Sublingual c) Coated tablet d) none of these 

One of the following is not a film defect

a) Picking & sticking b) Hazing c) Orange peel d) friability

Which is not mentioned in USP?

a) Weight uniformity b) Friability c) dissolution d) disintegration

 Lanolin in ointment Base

a) Hydrocarbon b) Adsorption base c) Water removable d) none of these 

 Anticodon of codon CGU

a) UHG b) UGC c) HGF d) GGF

Optical activity of the compound except

a) Plane of symmetry b) Axis of symmetry c) centre of symmetry d) None of

these

Tetrahedral structure of carbon is given by

a) Kakule b) Von Hoff and Lebel c) Erwin and Pasture d) Charls and Boyal

Iliac horns are seen in

A)Nail patella syndrome

B)ankylossing spondyliti

C)Both answer 1 and 2

D)None of these

In Sodium picrate test yellow color paper turn into brick red color. Brick red color of paper is due to

(A) Sodium picrate (B) Sodium isopurpurate

(C)sodiumpurpurate (D) HCN

red color with nitric acid is the characterstic test of

a) mucilage b) cellulose c) medulary rays d) mesophyll cells.

onset of action of NO is

a) 5 min b) 5 sec c) 2 min d) 50 sec

The ratio of cell constant and resistance in Conductometric titration is known as

a) EMF b) Specific conductance c) Standard potential d) none of

FOLLOWING IS >3J COUPLING?

A.GEMINAL COUPLING

B.VISINAL COUPLING

C.W COUPLING

D.ALL

Basal thermometer is used for

a)Temp Determination

b)Estim of time ovuation

c)Consistency of pharma products

d) Stability

Mass-Mass spectrometer is also known as

a) Double focusing b) Electrospray desorption c) Tandem d) Quadrupol

Aniline (aminobenzene) is made by

(a) direct amination

(b) nitration and oxidation

(c) nitration and reduction

(d) sulfonation and reduction

Unit of perfusion rate is

a) Ml/Min

b) Ml/Min/Ml

c) Ml/Min/kg

d) mcg/Ml.

Calcium oxalate crystals in Rauwolfia root are

a) Prismatic b) Cluster c) Acicular d) Rosette

Which of the following is a BBB permeation enhancer?

A.Cyclic amide

B.Diethyl nitrate

C.Dimethyl sulfoxide

D.Mannitol

best sterilisation method to sterilise a "Lab coat" is

a)     gaseous b) moist heat c) ionising radiation d) non ionising radiation

ZINGIBERENE is which type of sesquiterpene?

a) acyclic

b) monocyclic

c) bicyclic

d) tricyclic.ystrday ans withaferin

MEDICINAL CHEMISTRY

1. Pyrimethacine is derivative of

1. Pyridine

2. Pyrimidine

3. Acridine

4. None of above

2. Tolazoline is derivative of

1. 4,5-diydroimidazole

2. 2-imidazolidinedione

3. 5-imidazole

4. Pyrazolidinedione

3. Oxyphencyclamine is synthesized from

1. α-cyclohexyl-α-hydroxy-α-ph

enyl acetic acid

2. α-propionyl-p-chlorophenyl aceto nitrile

3. α-benzyl- α-methyl-p-hydroxy acetic acid

4. a & b

4. Pentetrazol contains,

1. 4 membered ring

2. 4 double bonds

3. Azepine nucleus

4. Diazepine nucleus

5. Van Braun’s method for opening of tetracyclic amines involves treatment of compound with

1. HCN

2. BrCN

3. ICI

4. CN-CH2-COOH

6. Reserpine on hydrolysis gives

1. Reserpic acid + Methyl alcohol + Trimethoxycinnamic acid

2. Reserpic acid + Acetic acid + Trimethoxybenzaldehyde

3. Reserpic acid + Methyl alcohol + Trimethoxybenzoic acid

4. Reserpic acid + Methyl alcohol + Trimethoxycinnamaldehyde

7. The factors affecting diffusion current in polarography can be given by which of following,

1. Nernst equation

2. Mark-Houwink equation

3. Lamberts law

4. Ilkovic equation

8. Thiotepa, a cytotoxic agent, is assay by titrating with

1. HCl

2. HClO4

3. Na2S2O3

4. KMnO4

9. IUPAC name of Pethidine is,

1. RS-dimethyl[1-phenyl-3-(phenot

hiazin-10-yl)propyl]amine

2. Ethyl-1-methyl-4-phenyl-piperi

dine-carboxylate

3. RS-1-isopropylamino-3-(1-nepht

hyloxy)-propon-2-ol

4. Propyl-4-carbamoylmethoxy-3-methoxy-phenyl acetate

10. The chemical reaction shown below can be carried out using following reagent, 

a. AlCl3

b. CuCl2

c. CH3COONa

d. CH3MgBr

PHARMACEUTICS

1. Angle of repose is directly or indirectly related to

A) bulk density b) porosity c) flowability d) particle size e) all 

2. Match the following

1. Lubricant a. Reduces frictional forces

2. Surfactant b. Reduces surface tensionremoves air

3. Glidant c. Increases compression time

4. Binder d. Reduces sticking

A) 1-d, 2-b, 3-c, 4-a b) 1-b, 2-d, 3-c, 4-a

C) 1-b, 2-d, 3-a, 4-c d) 1-d, 2-b, 3-a, 4-c

3. Porosity is 

A) void vol/bulk vol b) bulk vol/void vol c) bulk vol/true vol d) void density/bulk density

4. The problem of picking & sticking can be overcomed by all methods except

A) using tungsten carbide inserts in dies b) making punches faces smooth by adding silica

C) chromium plated punches faces d) using high melting point lubricants

5. Unit of area under curve (AUC) is

A) ml/min b) ml/min/ml c) mg/ml/min d) mg/min/ml 

6. A substance showing Mallard’s reaction is

A) hydrous lactose b) spray dried lactose c) anhydrous lactose d) freeze dried lactose

7. Mannitol is chiefly used in chewable tablets because of its

A) positive heat of solution b) negative heat of solution c) positive enthalpy d) negative enthalpy

8. Match the following hydrous silicon dioxide derivatives

1. Kaolin a. Magnessium

2. Talc b. Aluminium

3. Veegum c. Both aluminium & magnesium

4. Hectorite d. Zinc oxide

5. Calamine e. Fluorine & lithium

A) 1-d, 2-b, 3-c, 4-a,5-e b) 1-a, 2-b, 3-c, 4-e,5-d

C) 1-b, 2-a, 3-c, 4-e,5-d d) 1-d, 2-b, 3-a, 4-c,5-e

9. The derivative of Myricyl palmitate is used in the step of sugar coating

A) seal coating b) sub coating c) smoothing d) polishing

10. All are used as seal coating agents except

A) PEG b) shellac c) CAP d) oleic acid e) none

‎11. Opaque color concentrate for film coating is

A) opadry b) opaspray c) opalux d) opalact

12. Statement true about span is

1. W/o 2. O/w 3. Sorbitan esters 4. Poly sorbates

A) 2 & 4 b) 2 & 3 c) 1 & 3 d) 1 & 4

13. Eudragit is the brand name of

A) CAP b) ethyl cellulose c) microcrystalline cellulose d) acrylates 

14. Bentonite is 

A) o/w b) w/o c) o/w/o d) both a & b

15. The metal present in gelatin is

A) iron b) selenium c) magnesium d) cooper e) cobalt

16. Particle size for Multiorifice centrifugal microencapsulation technique in micrometer is

A) 35-5000 b) 600-5000 c) 5-5000 d) 1-5000

17. Propellent number 11 best suits for

A) trichloromonofloromethane b) dichlorodifloromethane c) dichlorotetrafloroethane d) none

18. Aerosoles can be evaluated for particle size by all techniques except

A) microscopy b) x-ray diffraction c) cascade compactor d) electrophoresis

19. “Dispersion medium air & dispersed phase water in high amount” we are talking about

A) fog b) smoke c) mist d) gel

20. All are penetration enhancers except

A) DMF b) DMSO c) DHP d) ozone e) none

21. An instrument used to calculate surface area is

A) interferometer b) sorptometer c) chilsonator d) ketonameter

22. Cloud point is the characterstic feature of

A) ceterimide b) macrogols c) lecithin d) SLS

23. HLB value for a w/o emulsifying agent is

A) 8-16 b) 3-8 c) 1-3 d) x>16

24. Quantasorb is used to measure

A) surface area b) particle size c) particle number d) viscosity

25. Contact angle of an ideal wetting agent should be

A) zero b) less than 10 c) 10-15 d) more than 15

26. Identify the wrong statement

A) zeta potential can be negative b) spreading coefficient can be zero

C) zeta potential can be zero d) spreading coefficient can be negative

27. An emulsion of concentration 20-50% shows characterstical flow

A) plastic b) dilatant c) pseudoplastic d) newtonian

28. Emulsifying agent form laminaria is

A) acacia b) tragacanth c) shellac d) alginates

29. Hydrous wool fat (lanolin) is the type of ointment base

A) hydrocarbon b) water miscible c) water soluble d) absorption e) adsoption