How many amino acid are present in proinsulin?
(a) 51 (b) 61
(c) 84 (d) 31
ans=c.
ampicillin,amoxicillin are especially used for t/t of?
a)urinary tract infections b)menigitis c)respiratory tract inf. d)skin inf.
ans=c
Below two are the examples of drugs used in cytomegalovirus infection?
(P) foscarnet (Q)trifluridine (R)idoxouridine (S)vidarabine
Ans=P & R
loss of colour in multivitamin suspension is an example of?
(a) zero order process (b)1st order (c)2nd order (d)pseudo 1st order
ans=a
Drugs metabolized by acetylation----
' SHIP'
Sulfonamides including dapsone
Hydralazine
Isoniazid (INH)
Procainamide
Antibiotics contraindicated in pregnancy--
' MCAT '
Metronidazole
Chloramphenicol
Aminoglycosides
Tetracyclines
Enzyme inducer---
"PARAG"
Phenylbutazone
Anticonvulsants
Rifampicin
Alcohol
GRISEOFULVIN
ENZYME INHIBITORS-
Cimetidine
Omeprazole
Metronidazole
Isoniazid
Chloramphenicol
Ciprofloxacin
Allopurinol
Sulphonamides
Erythromycin
ENZYME-COFACTORS
DNA polymerase-Zn+
Hexokinase,Glucose-6-Phosphate-Mg+2
Arginase-Mn+2
Nitrate reductase-Mo
Catalase,Peroxidase-Fe+2.
Which of the following drug is used as children anaesthetic?
a.ketamine
b.propofol
c.halothane
d.alphaxolone
ans=a.
Sulfonyl urea used in the t/t of diabetis during pregnancy-GLYBURIDE.
Drug used in the diagnosis of "MYASTHENIA GRAVIS"-Edrophonium
drugs & synonym:
MANDUKI-BRAHMI
Ephedra-Ma hung
D.pupurea-Fox glove
Chhota chand-RAUWOLFIA
Datura-Thorn apple
DEADLY NIGHTSHADE-BELADONA
Particle size by each mill (micron):
a.sieveing:1-1000
b.centrifugation:0.1-5
c.Elutriation:0.5-50
d.Cyclone separation:2-50
Taste&flavour:
Salty:vanila,mapl,peach,butterscotch,mint
Bitter:wild cherry,walnut,anise
Sweet:berry,vanilla
Sour:raspbery,root beer,fruit
A compound after TLC identified by spraying antimony trichloride.
Identify the drug
a)saponins b)carotenoids c)cardinolides d)tannins
ans=b
Cheese reaction of MAO inhibitor seen with beer,yeast,wine,soy extrct,cheese.
thioridazone withdrawn(cardiac K+ channel block)
Coulter counter is used in determination of
(A) particle surface area (B) particle size
(C) particle volume (D)all of A, B, C
ans=d..
Polarography
Diffusion current is due to electro reduceble ion
Migration current is due to supporting electrolyte
Tetracycline uses:
(TIPS: ABC PaRiVaR)
Atypical pneumonia
Brucellosis
Cholera
Plague
Recurrent fever
Veneral dss
Ricketsial
SUCROSE BASED DILUANTS
Dipac -97%sucrose+3% moddified dextrose
Nutab -95%sucrose+4% invert sugar
Sugar tab -90-93%sucrose+7-10%invert sugar
Spans 20=Sorbitan mono laurate
Tween 80=Polyoxyethylene sorbitan monooleate
L:Laurate-20
P:Palmitate-40
S:Stearate-60
O:Oleate-80
remembr d
PROPORTIONS REQUIRED FOR A PRIMARY EMULSION
(oil:water:gum)
Fixed oils :-4:2:1
Volatile oils:- 2:2:1
Mineral oils:-3:2:1
Oleoresins:-1:2:1
What is ALCON & POLYQUAD used in Opthalmic?
A) Preservative
B) Solubility enhancer
C) Antioxidant
D) All of above
ans=A...
OH shows a characterstic IR peak at cm-1 a) 1725 b) 3200 c) 3650 d) 2300
ans=c..
Do all IR peaks from std books like Pavi/Skoog/silver stein.
Guanidium thiocyanate, CTAB-cetyl trimethyl ammonium bromide,
Ethidium bromide-this all are uesd in DNA isolation.
Amide is converted in to amine.
identify the rearrangement
a)Backmann
b)Curtius
c)Pinacole
d)Hoffmann
ans=d.
plz remember this values....
DIGITALIS:1 IU=76mg std
VIT A:1 IU=0.344mg std
VIT D:1 IU=0.025mg std
Heparin:1 IU=7.7mg std
INSULIN 1 IU=0.
Sodium glucose co-transporter-2 (SGLT2) inhibiting antidiabetics:
Canagliflozin
Dapagliflozin,
Remogliflozin,
Sergliflozin.
This is new class.
Drug usd in severe Alzeimer's disease:
A.Memantine
B.Ifenprodin
C.Aniracetam
D.Neostigmine
Ans=A
GABA-B agonist is:
A.Phaclofen
B.Baclofen
C.Saclofen
D.All of above
ans=d..
Donepezil, Isoflurophate & Neostigmine are anticholinesterase with longer action..
edrophonium-shorter acting anticholinesterase.
DRUG-SYNONYM
Devil's dung-Asafoetida
Chaumogra oil-Hydnocarpus
Tylophora-Anantmul
Ephedra-Ma hung
Datura-Thorn apple
D.pupurea-Fox glove
Zanasi- capsule filling (powder,pellets,tablets)
Lily/parke-davis: capsule filling (powder)
Farmatic, holfiger & kary-liquid filling in HGC
Erweka:- De-dusting and polishing capsule machine.
Seidender- Uses a Belt for visual inspection.
Vericap 1200- capsule weighing machine
Penicillin G: benzyl penicilin
penicilin X: p-OH benzyl
Penicillin K: n-heptanyl
Penicillin V: phenoxy methyl
Penicillin F:2-pentanyl
Imipenam given with Cilastatin cz Cilastatin inhibits dehydopeptidase enzyme dt is responsible for hydrolysis of Imipenam.
In hepatic coma(encephalopathy), drug used are:
Lectulose,Neomycin,Metronidazole.
FOR TRANSDERMAL DRUG DELIVERY SYS:
DRUG:
LOW MELTING PT(<200 C)
POTENT
SHORTER T1/2
NONIONIC
LOG P VALUE(1-3)
MOL WT(<1000 DALTON)
Transdermal Drug Delivery Sys:
Major barrier dt prevent drug absorption is STRATUM CORNEUM,located in epidermis of skin,100-150 micron thick
Monitoring of plasma drug concentration is required while using:
A.Antihypertensive drug
B.Levodopa
C.Lithium carbonate
D.MAO inhibitor
ANS=C
Chitin gets converted in to Chitosan upon:
A.Acetylation
B.Deacetylation
C.Oxidation
D.Reduction
ANS=B..
which of the Anthelmintics having Immunosuppressant activity?
A.Piperazine
B.Levamisole
C.Ivermectin
D.Niclosamide
ans=b..
Quinidine prolongs t1/2 of propafenone nd inhibits conversion of codiene 2 morphine.
Ergometrine is used in diagnosis of variant angina.
BENTONITE is a hydrated alluminum silicate
Veegum- is a magnesium alluminum silicate
acacia is a salt of d-glucuronic acid
time to reach Css is
-dependent on t1/2 & Ke
-independent on dose size,dosing freq& dose number.
fenoldopam-selective dopamine D1 receptor agonist, for severe hypertension
Enalkerin-orally active renin inhibitor
penicillin-penam(ring)
Cephalosporins-cepham & cephem
clavulanic acid-oxopenam
thienamycin,imipenam,meropenam-carbapenam
aztreonam-monobactam
Method for Particle size determinatn-Anderson pipet
for Particle volume-Coulter counter
for surface area-Air permeability method.
(+) limonene present in lemon & orange
(-) limonene in peppermint
(+/-) presnt in turpentine.
(+) limonene present in lemon & orange
(-) limonene in peppermint
(+/-) presnt in turpentine.
Moxifloxacin & Gatifloxacin are 4th generation quinolones owing to dr activites against anerobes & S. pneumoniae.
Local anesthetic: Clove
Sedative: Jatamansi
Local irritant: Turpentine
Insect Repellant: Citronella oil
Vit A: lemon grass oil
use of volatile oil c'ning drugs:
Anthelmintic: Chenopodium
Diuretic: Juniper
Antiseptic: Eucalyptus
Counter irritant: winter green
Shatavari contain 4 steroidal saponin: shatavarin I,II,III,IV
shatavarin I-anxiolytic
othr use of ds drug is-diuretic,galactogue..
Live vaccine-BCG
Dead vaccine-cholera & typhoid
Toxoid-diptheria
Ricketsial-typhus
Addition of HBr to cis-2-butene produces
A.1-bromobutane
B.2-bromobutane
C.1,2-dibromobutane
D.2,3-dibromobutane
ans=c..
Nanosuspension used 4 drug with poor solubility&low bioavaibility.
It incrs saturation solubility,dissolution velocity&adhesiveness to surface.
Electrostatically stabilized nanosuspensn hv min. (p'cle charge) zeta potential +/-30mv while steric&electrostatic stabilized hv min +/-20mv.
In-vivo evaluatn of Gastro retentive dosage form:gamma scintigraphy,gastroscopy,magnetic marker,ultrasonography,13C octanoic acid breath test
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