some important drugs and their mechanism of action
Drug mechanism of action
Allopurinol inhibits the enzyme xanthine oxidase, involved in the synthesis of Uric acid
Antipsychotics: acts by blocking dopamine receptors.
Aspirin inhibits enzyme cyclooxygenase and prevents synthesis of prostaglandins
Acetazolamide inhibits carbonic anhydrase used as diuretics
Aminoglycosides binds to 30 S ribosome and inhibit protein synthesis.
Acyclovir incorporated in to viral DNA and inhibits viral replication.
Amantadine inhibits viral attachment and uncoating
Benzodiazepines act on benzodiazepines receptors and facilitate the effect of GABA.
Cimetidine blocks H2 receptors.
Chloramphenicol
Tetracycline’s, erythromycin bind to 50 S and inhibit protein synthesis.
Griseofulvin acts as anti- fungal interferes with mitotic spindle structure
Isoniazid inhibits the synthesis of mycolic acid, imp. Part of cell wall of mycobacterium
Nalidixic acid prevents DNA synthesis
Warfarin antagonize the action of vitamin K
Primethamine block folic acid production by acting on dihydrofolate reductase
Penicillin acts on cell wall
Sulfinpyrazole and probenecid block uric acid reabsorbtion at PCT
Sodium valproate inhibits the enzyme GABA transaminase…thus increase the action of GABA
Spironolactone inhibits the action of aldosterone
Vinca alkaloids bind to tubulin fibers and inhibit mitosis
Zidovudine inhibits the enzyme reverse transcriptase and inhibits the synthesis of viral DNA
Dapsone inhibition of PABA incorporation into folic acid.
Polyene class; acts as anti-fungal and attach to ergosterol n fungal cell wall
Terbinafine competitive inhibitor of squalene epoxidase acts as anti-fungal
Metronidazole cytotoxic in nature and cause damage to DNA
Mebendazloe acts on β- tubulin of parasite, similar mechanisms for class azoles.
